It is challenging to obtain accurate histories of maternal smoking during pregnancy using interviews, because mothers may have trouble remembering their past smoking habits or they may be reluctant to discuss their smoking habits during pregnancy. Moreover, maternal smoking causes other negative birth outcomes, which obscure our ability to measure leukemia risk. Both of these factors could help explain why we did not observe an association between maternal smoking during pregnancy and childhood leukemia overall. Interestingly, maternal smoking during pregnancy and during breastfeeding increased the risks of childhood ALL with chromosome deletions, but not RAS mutations.
Childhood leukemia is a heterogeneous cancer, and our study suggests that the relationship between parental smoking and childhood leukemia is complex, depending on the molecular leukemia subtypes. The full articles are available here.[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][mk_divider style=”thick_solid” margin_bottom=”40″][/vc_column][/vc_row][vc_row][vc_column width=”1/2″][mk_fancy_title color=”#c4820e” size=”16″ font_family=”none”]Parental Smoking in the Childhood Leukemia International Consortium[/mk_fancy_title][vc_column_text css=”.vc_custom_1598573630791{margin-bottom: 0px !important;}”]The Childhood Leukemia International Consortium (CLIC) strengthened the evidence of a modest association between paternal smoking and the second-most common subtype of childhood leukemia — acute myeloid leukemia (AML) — using a pooled analysis of 1,330 children with AML, the largest study to date. We found dose-response relationships, meaning that leukemia risk increased with an increasing number of cigarettes the father smoked. No associations were observed between AML and maternal smoking any time before or after birth, except possibly for Latina mothers participating in the CLIC studies from California and Washington states, Mexico, and Costa Rica.[/vc_column_text][/vc_column][vc_column width=”1/2″][mk_image src=”https://live-circle-icare.pantheon.berkeley.edu/wp-content/uploads/2022/05/smoking-and-aml-from-clic.png” image_size=”full” frame_style=”gray_border”][mk_fancy_title margin_bottom=”5″ font_family=”none”]
The risk of childhood acute myeloid leukemia associated with parental smoking during various developmental windows.
[/mk_fancy_title][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1598573642257{margin-bottom: 0px !important;}”]References:de Smith AJ, Kaur M, Gonseth S, et al. Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res. 2017;77(7):1674-1683. doi:10.1158/0008-5472.CAN-16-2571
Kaur M, de Smith AJ, Selvin S, et al. Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia. Arch Med Res. 2016;47(8):677-683. doi:10.1016/j.arcmed.2016.11.016[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][mk_padding_divider][/vc_column][/vc_row][mk_page_section bg_color=”#003262″ border_color=”#003262″ bg_stretch=”true” js_vertical_centered=”true” sidebar=”sidebar-1″][vc_column width=”1/4″][mk_padding_divider size=”100″][mk_image src=”https://live-circle-icare.pantheon.berkeley.edu/wp-content/uploads/2022/04/headerbanner_fit.png” image_size=”medium” link=”https://dev-circle-icare.pantheonsite.io/”][/vc_column][vc_column width=”1/4″][mk_padding_divider][mk_fancy_title size=”16″ margin_bottom=”0″ font_family=”none”]
Return to the house and explore other rooms:
[/mk_fancy_title][mk_image src=”https://live-circle-icare.pantheon.berkeley.edu/wp-content/uploads/2022/05/circle-leukemia-risk-factors-at-home-300×190-1.png” image_size=”medium” frame_style=”gray_border” link=”https://dev-circle-icare.pantheonsite.io/exposures-of-interest/”][/vc_column][vc_column width=”1/4″][mk_padding_divider size=”10″][mk_icon_box2 icon_size=”64″ icon=”mk-icon-question” icon_color=”#ffffff” icon_border_color=”#ffffff” icon_hover_color=”#003262″ icon_hover_background_color=”#ffffff” icon_hover_border_color=”#ffffff” title=”Fact Sheets” title_color=”#ffffff” description_color=”#ffffff” read_more_url=”https://dev-circle-icare.pantheonsite.io/news/factsheets/”]Still have questions? Link to other helpful sources of information on childhood leukemia and its risk factors.[/mk_icon_box2][/vc_column][vc_column width=”1/4″][mk_padding_divider size=”60″][vc_column_text css=”.vc_custom_1652714661419{margin-bottom: 0px !important;}”]CONTACTCIRCLE
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