Childhood Cancer 2016, September 29, 2016.

Mark Miller, M.D., MPH

Can we reduce exposure to risk factors associated with childhood leukemia and other cancers?

Dr Miller meets with ecancertv at Childhood Cancer 2016 to discuss a survey of healthcare providers that revealed a gap in awareness about environmental risk factors for childhood cancer.  Tobacco use, air pollution, and diet are among the risk factors for childhood leukemia, with important windows of exposure occurring even before conception.  Dr Miller describes the need for wider awareness and public engagement by oncologists on regional and national levels to communicate preventative behaviours more fully.  The video was produced by ecancertv.

Environmental Health Through the Lifespan: Making the Connection in 2016, February 26, 2016

Mark Miller, M.D., MPH

Childhood Leukemia: A Preventable Disease?

Dr. Miller discusses strategies for translating childhood leukemia research into clinical practice. Follow the link at the left to the University of Wisconsin Video Library. Dr. Miller’s talk begins at the 5:25 minute mark. Alternatively, use the Chapter Tab at the bottom of the University of Wisconsin Video Library page to jump ahead to ‘Childhood Leukemia: A Preventable Disease?’

EnviroHealthBerkeley YouTube Series

Todd Whitehead, Ph.D.

Contaminated Dust in Homes and Children’s Health

Dr. Whitehead discusses how harmful chemicals including PCBs and flame retardants are found in household dust. His studies show that such chemicals remain in dust for years. Children are at greatest risk of exposure because they play on floors and tend to ingest dust. He shows that these chemicals were found in dust samples collected for the purposes of investigating the causes of childhood leukemia.

Todd Whitehead, Ph.D.

Measuring Contaminants in Dust

Dr. Whitehead explains how to measure chemicals in settled dust collected from homes. Some chemicals found in household dust are harmful to children. He works with samples collected by regular vacuum cleaners.

Todd Whitehead, Ph.D.

A Legacy of Contaminated Dust

Dr. Whitehead explains the legacy of banned industrial chemicals; the uses of these chemicals were discontinued year ago, but they can still be found in pretty much any home, even today.

Symposium on Cumulative Impacts and Children’s Environmental Health, January 2013

Todd Whitehead, Ph.D.

Approaches to Considering Cumulative Exposures for Children

Dr. Whitehead brings together information from several types of exposure assessments conducted for studies of causes of leukemia in children by CIRCLE.  He shows that some contaminants occur together in homes and shows new ways to portray and study such cumulative exposures. Reducing cumulative burdens of such contaminants is essential to protect children.

CIRCLE External Scientific Advisory Committee Meeting, October 2012

Stephen Rappaport, Ph.D.

The Exposome Paradigm: Using Untargeted Approaches to Discover Causes of Disease

Dr. Rappaport advocates for studies of the whole “exposome”.

Joseph Wiemels, Ph.D.

Environmental Exposures and Methylation Changes in Blood Spots

Dr. Wiemels explains how environmental factors can cause epigenetic changes that control development and many other aspects of human biology. In this presentation, Dr. Wiemels highlights methods to measure early epigenetic changes that may contribute to disease. He discusses one form of epigenetic changes, known as methylation, measured in small samples of blood collected on cards.

Todd Whitehead, Ph.D.

Using Household Dust to Measure Children’s Chemical Exposures in Homes

Dr. Whitehead explains how CIRCLE investigators use household dust samples to measure children’s exposure to chemicals in the home.

Joseph Wiemels, Ph.D.

The Importance of Epigenetic Changes

Dr. Wiemels discusses the role epigenetics plays is typical human development and shows what epigenetic changes can occur in children with leukemia.

Catherine Metayer, M.D., Ph.D.

Founding of the Childhood Leukemia International Consortium

The Childhood Leukemia International Consortium brings together researchers from many countries to work together to better understand childhood leukemia.

Patricia Buffler, Ph.D.

How CIRCLE was Created

The late Dr. Patricia Buffler, founding Director of CIRCLE, explains how the Center was created in 2009, building on the California Childhood Leukemia Study.

Children’s Environmental Health Symposium: Emerging Research and Implications for Risk Assessment and Policy, January 2012

Catherine Metayer, M.D., Ph.D.

Use of Chemicals at Home and Risk of Childhood Leukemia

Dr. Metayer discusses chemical risk factors for childhood leukemia.  She indicates that use of pesticides in the home, particularly during the prenatal period, may increase risk of childhood leukemia. She indicates that use of paint in the home after pregnancy may increase risk of childhood leukemia.  The introduction is by Dr. Melanie Marty of the Office of Environmental Health Hazard Assessment of Cal EPA.

Patricia Buffler, Ph.D.

Parents’ smoking increases risks of leukemia in their children

The late Dr. Buffler presents data from the California Childhood Leukemia Study showing that children whose parents smoked are more likely to develop leukemia in early childhood. Risks vary by the time period of smoking (preconception, prenatal, and early childhood), type and subtype of leukemia, and which parents smoked.

Joseph Wiemels, Ph.D.

Environmental Exposures, Childhood Leukemia and the Role of DNA Methylation

Dr. Wiemels explains the importance of epigenetics. Epigenetic changes do not damage DNA (like mutations), but alter the way that DNA is expressed. This can affect development in early life. Aberrant epigenetic changes may cause some types of leukemia. Leukemia includes a number of different diseases with different patterns of epigenetic markers including methylation. Environmental agents may change methylation patterns, and the changes may be heritable.

Stephen Francis, Ph.D.

Could Infection Contribute to a Possible Leukemia Cluster in Fallon?

Dr. Francis discusses whether infectious agents may have contributed to a possible cluster of childhood leukemia cases in Fallon, Nevada. A role for an infectious agent, in this case a virus, is suggested because there was a spike in cases of childhood leukemia in US military dependent populations at around the same time; Fallon had a naval air station that brought military personnel into the town; and the locations where children with the disease lived tended to be in areas where transmission by mosquitoes might occur.

Todd Whitehead, Ph.D.

Using House Dust to Measure Chemicals Affecting Children

Dr. Whitehead shows that dust from houses can be used to measure chemicals that children are exposed to at home, particularly PAHs, PCBs, PBDEs, and tobacco smoke constituents. He shows that measurements taken several years after a child is born are useful to estimate earlier exposure.