Welcome to the Center for Integrative Research on Childhood Leukemia and the Environment

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CIRCLE's scientists collaborate in new ways and use the latest methods to search for the causes of leukemia in children. Leukemia is the cancer that is most commonly diagnosed in children, so it is very important to find its causes and do whatever we can to eliminate them.

CIRCLE was founded by Professor Patricia Buffler, who has passed away. Catherine Metayer has succeeded her as principal investigator to continue research to discover causes of leukemia.

We have learned that there are several different kinds of leukemia that probably have different causes. We have to separate these out to be able to see the causes of the disease.

We are looking at exposures that occur in people’s houses to see whether they cause leukemia. We have learned a lot about contaminants that are in house dust.

We work with investigators all around the world through the Childhood Leukemia International Consortium (CLIC). The power of greater numbers can speed research. Visit the web site for CLIC

Investigators with CIRCLE also work on many other projects. For example, the California Childhood Leukemia Study (CCLS), started in 1995 by founding CIRCLE Director Patricia Buffler, is one of the largest studies of this subject in the world. Visit the web site for the CCLS Study

Symposium on Cumulative Impacts and Children's Environmental Health. View the Videos and Resources here.
Project Leader Joe Wiemels presented at the Inaugural Clinical Epigenome Conference in June at a session on Mechanisms on (de) Methylation Underlying Disease. His topic was DNA Methylation Changes in Pre-B Cell Development and Childhood Leukemia.
Cancer Epidemiology published an article by CIRCLE investigators and collaborators explaining how the Childhood Leukemia International Consortium fills gaps in knowledge about the role of environmental and genetic risk factors, critical windows of exposure, and effects of gene-environment interactions. See the abstract at Pubmed