Core A: Community Outreach and Research Translation

Whitehead TP, Metayer C, Wiemels JL, Singer AW, Miller MD. Childhood Leukemia and Primary Prevention. Curr Probl Pediatr Adolesc Health Care. 2016 Oct;46:317-52. (PMC ID: Not yet assigned)

Zachek CM, Miller MD, Hsu C, Schiffman JD, Sallan S, Metayer C, Dahl GV. Children’s Cancer and Environmental Exposures: Professional Attitudes and Practices. J Pediatr Hematol Oncol. 2015 Oct;37(7):491-7. (PMC ID: 4571458)

Jump Link #1.

Childhood Leukemia International Consortium

Marcotte EL, Thomopoulos TP, Infante-Rivard C, Clavel J, Petridou ET, Schüz J, Ezzat S, Dockerty JD, Metayer C, Magnani C, Scheurer ME, Mueller BA, Mora AM, Wesseling C, Skalkidou A, Rashed WM, Francis SS, Ajrouche R, Erdmann F, Orsi L, Spector LG.  Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC).  Lancet Haematol. 2016; 3(4):e176-85. (PMC ID: in process)

Metayer C, Milne E, Clavel J, Infante-Rivard C, Petridou E, Taylor M, Schuz J, Spector LG, Dockerty JD, Magnani C, Pombo-de-Oliveira MS, Sinnett D, Murphy M, Roman E, Monge P, Ezzat S, Mueller BA, Scheurer ME, Armstrong BK, Birch J, Kaatsch P, Koifman S, Lightfoot T, Bhatti P, Bondy ML, Rudant J, O’Neill K, Miligi L, Dessypris N, Kang AY, Buffler PA. The Childhood Leukemia International Consortium. Cancer Epidemiol. 2013; 37(3):336-347. (PMC ID: 3652629)

Metayer C, Milne E, Dockerty JD, Clavel J, Pombo-de-Oliveira MS, Wesseling C, Spector LG, Schuz J, Petridou E, Ezzat S, Armstrong BK, Rudant J, Koifman S, Kaatsch P, Moschovi M, Rashed W, Selvin S, McCauley K, Kang AY, Hung RJ, Buffler PA, Infante-Rivard C. Maternal supplementation with folic acid and other vitamins before and during pregnancy and risk of leukemia in the offspring: A childhood leukemia international consortium (CLIC) study. Epidemiology. 2013; 73(8). (PMC ID: in process)

Bailey H, Fritschi L, Infante-Rivard C, Glass DC, Miligi L, Dockerty JD, Lightfoot T, Clavel J, Roman E, Spector LG, Kaatsch P, Metayer C, Magnani C, Milne E, Polychronopoulou S, Simpson J, Rudant J, Sidi V, Rondelli R, Orsi L, Kang A, Petridou E, Schuz J. Parental occupational pesticide exposure and the risk of chilhdood leukemia in the offspring: findings from the Childhood Leukemia International Consortium. Int. J. Cancer. 2014;135(9):2157-72). (PMC ID: 24700406)

Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C. Global characteristics of childhood acute promyelocytic leukemia. Blood Rev. 2014; 29(2):101-25. (PMC ID: 4379131)

**Milne E, Greenop KR, Metayer C, Schuz J, Petridou E, Pombo-de-Oliveira MS, Infante-Rivard C, Roman E, Dockerty JD, Spector LG, Koifman S, Orsi L, Rudant J, Dessypris N, Simpson J, Lightfoot T, Kaatsch P, Baka M, Faro A, Armstrong BK, Clavel J, Buffler PA. Fetal growth and childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium (CLIC). Int. J. Cancer. 2013; 133(12):2968-2979. (PMC ID: 3797193)

**Bailey H, Fritschi L, Metayer C, Infante-Rivard C, Magnani C, Petridou E, Roman E, Spector LG, Kaatsch P, Clavel J, Milne E, Dockerty JD, Glass DC, Lightfoot T, Miligi L, Rudant J, Baka M, Rondelli R, Amigou A, Simpson J, Kang AY, Moschovi M. Parental occupational paint exposure and risk of childhood leukemia in the offspring: Findings from the Childhood Leukemia International Consortium. Cancer Causes Control. 2014; 25(10):1351-1367. (PMC ID: in process)

**Rudant J, Lightfoot T, Urayama K, Petridou E, Dockerty J, Magnani C, Milne E, Spector L, Ashton L, Dessypris N, Kang A, Miller M, Rondelli R, Simpson J, Stiakaki E, Orsi L, Roman E, Metayer C, Infante-Rivard C, Clavel J. Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium (CLIC) Study. Am. J. Epidemiol. 2014; 181(8):549-62. (PMC ID: in process)

**Bailey HD, Metayer C, Milne E, Petridou E, Infante-Rivard C, Spector LG, Clavel J, Dockerty JD, Zhang L, Armstrong BK, Rudant J, Fritschi L, Amigou A, Chatzipadelis E, Kang AY, Stiakaki E, Joachim Schüz. Home paint exposures and risk of childhood acute lymphoblastic leukemia: Findings from the Childhood Leukemia International Consortium. Cancer Causes Control; 2015 26(9):1257-70. (PMC ID: in process)

**Denotes an ancillary manuscript partially supported by CIRCLE

Jump Link #2.

Project 2: Identifying In Utero Exposures that Are Risk Factors for Childhood Leukemia (Exposome)

Li H, Grigoryan H, Funk WE, Lu SS, Rose S, Williams ER, Rappaport SM. Profiling Cys34 adducts of human serum albumin by fixed-step selected reaction monitoring. Mol Cell Proteomics. 2011; 10(3):M110 004606. (PMC ID: 304715)

Whitehead TP, Brown FR, Metayer C, Park JS, Does M, Petreas MX, Buffler PA, Rappaport SM. Polybrominated diphenyl ethers in residential dust: sources of variability. Environ. Int. 2013; 57-58(0):11-24. (PMC ID: 3668857)

Whitehead T, Metayer C, Buffler P, Rappaport SM. Estimating exposures to indoor contaminants using residential dust. J Expo Sci Environ Epidemiol. 2011; 21(6):549-564. (PMC ID: in process)

Whitehead T, Metayer C, Gunier RB, Ward MH, Nishioka MG, Buffler P, Rappaport SM. Determinants of polycyclic aromatic hydrocarbon levels in house dust. J Expo Sci Environ Epidemiol. 2011; 21(2):123-132. (PMC ID: 2891419)

Whitehead T, Ward MH, Colt JS, Nishioka MG, Buffler PA, Rappaport SM, Metayer C. Determinants of polychlorinated biphenyls in dust from homes in California, USA. Environmental Science: Processes & Impacts. 2013; 15(2):339-346. (PMC ID: 4439093)

Whitehead TP, Metayer C, Park JS, Does M, Buffler PA, Rappaport SM. Levels of nicotine in dust from homes of smokeless tobacco users. Nicotine Tobacco Res. 2013; 15(12):2045-2052. (PMC ID: 3819978)

Whitehead TP, Metayer C, Petreas MX, Does M, Buffler PA, Rappaport SM. Polycyclic aromatic hydrocarbons in residential dust: sources of variability. Environ. Health Perspect. 2013; 121(5):543-550. (PMC ID: 3672903)

Whitehead TP, Brown FR, Metayer C, Park JS, Does M, Dhaliwal J, Petreas MX, Buffler PA, Rappaport SM. Polychlorinated Biphenyls in Residential Dust: Sources of Variability. Environ. Sci. Technol. 2014; 48(1):157-164. (PMC ID: 3941978)

Whitehead TP, Metayer C, Ward MH, Colt JS, Gunier RB, Deziel NC, Rappaport SM, Buffler PA. Persistent organic pollutants in dust from older homes: learning from lead. Am. J. Public Health. 2014; 104(7):1320-1326. (PMC ID: 4056196)

Whitehead TP, Crispo Smith SM, Park JS, Petreas MX, Rappaport SM, Metayer C. Concentrations of persistent organic pollutants in California children’s whole blood and residential dust. Environ Sci Technol. 2015; 49(15):9331-40. (PMC ID:  in process)

Whitehead TP, Crispo-Smith S, Park JS, Petreas MX, Rappaport SM, Metayer C. Concentrations of persistent organic pollutants in California women’s serum and residential dust. Environ. Res. 2015; 136:57-66. (PMC ID:  4262624)

**Brown FR, Whitehead TP, Park JS, Metayer C, Petreas MX. Levels of non-polybrominated diphenyl ether brominated flame retardants in residential house dust samples and fire station dust samples in California. Environ. Res. 2014; 135C(0):9-14. (PMC ID: 4262617)

**Wagner J, Ghosal S, Whitehead T, Metayer C. Morphology, spatial distribution, and concentration of flame retardants in consumer products and environmental dusts using scanning electron microscopy and Raman micro-spectroscopy. Environ. Int. 2013; 59(0):16-26. (PMC ID: 3759544)

**Denotes an ancillary manuscript partially supported by CIRCLE

Jump Link #3.

Project 3: Prenatal Exposures, Constitutive Genetics, DNA Methylation & Childhood Leukemia (Epigenetics)

Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL. Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics. 2015 10(12):1166-76. (PMC ID: 4844202)

Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL. A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012; 40(22):11339-11351. (PMC ID: 3526268)

Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res. 2015 Mar 11;43(5):2590-602. (PMC ID: 4357708)

Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith AJ, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int. J. Cancer. Sep 1 2014; 135(5):1101-1109. (PMC ID: 24496747)

Vasconcelos GM, Christensen BC, Houseman EA, Xiao J, Marsit CJ, Wiencke JK, Zheng S, Karagas MR, Nelson HH, Wrensch MR, Kelsey KT, Pombo-de-Oliveira MS, Wiemels JL. History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia. Epigenetics : official journal of the DNA Methylation Society. Dec 2011; 6(12):1436-1443. (PMC ID: 3256332)

**Francis SS, Selvin S, Metayer C, Wallace AD, Crouse V, Moore TB, Wiemels JL, Buffler PA. Mode of delivery and risk of childhood leukemia. Cancer Epidemiol. Biomarkers Prev. May 2014; 23(5):876-881. (PMC ID: In Process)

**De Smith AJ, Walsh KM, Zhang S, Xiao C, Cohen F, Moore TB, Chokkalingam AP, Metayer C, Buffler PA, Trachtenberg EA, Wiemels JL. The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood. 2014;123(16):2497-503. (PMC ID: 3990912)

**Denotes an ancillary manuscript partially supported by CIRCLE

Jump Link #4.

Other Relevant Publications (Not Funded by CIRCLE)

Chang JS, Selvin S, Metayer C, Crouse V, Golembesky A, Buffler PA.  Parental smoking and the risk of childhood leukemia. Am J Epidemiol. 2006;163(12):1091-100.  (PMC ID: in process)

Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. Tobacco smoke exposure and the risk of childhood acute lymphoblastic and myeloid leukemias by cytogenetic subtype.  Cancer Epidemiol Biomarkers Prev. 2013;22(9):1600-11. (PMC ID: 3769478)

Ma X, Buffler PA, Gunier RB, Dahl G, Smith MT, Reinier K, Reynolds P. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect. 2002;110(9):955-60. (PMC ID: 1240997)

Scélo G1, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA. Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect. 2009;117(1):133-9.  (PMC ID: 2627857)

Bartley K, Metayer C, Selvin S, Ducore J, Buffler P. Diagnostic X-rays and risk of childhood leukaemia. Int J Epidemiol. 2010;39(6):1628-37. (PMC ID: 2992630)

Chokkalingam AP1, Bartley K, Wiemels JL, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Chang JS, Month SR, Wiencke JK, Buffler PA. Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control. 2011;22(12):1721-30. (PMC ID: 3206192)

Ward MH, Colt JS, Metayer C, Gunier RB, Lubin J, Crouse V, Nishioka MG, Reynolds P, Buffler PA. Residential exposure to polychlorinated biphenyls and organochlorine pesticides and risk of childhood leukemia. Environ Health Perspect. 2009;117(6):1007-13. (PMC ID: 2702395)

Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, Nishioka M, Dahl GV, Rappaport SM, Buffler PA, Metayer C. Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California. Environ Health Perspect. 2014;122(10):1110-6.  (PMC ID: 4181922)

Deziel NC, Rull RP, Colt JS, Reynolds P, Whitehead TP, Gunier RB, Month SR, Taggart DR, Buffler P, Ward MH, Metayer C. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environ Res. 2014;133:388-95. (PMC ID: 4119528)